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Fibrosure in North America), and another consists of hyaluronic acid, tissue inhibitor of metalloproteinase (TIMP)-1, and a-2-macroglobulin (marketed as FibroSpect II).28 The European Liver Fibrosis Group has recently proposed an algorithm combining age, hyaluronic acid, amino-terminal propeptide of type III collagen, and tissue inhibitor of matrix metalloproteinase 1 for detecting liver fibrosis.29 If these noninvasive markers can be proven to have consistently good positive and negative predictive value for hepatic fibrosis, then liver biopsy may be obviated in even more C282Y homozygotes in the future

doi: 10.1046/j.1365-2044.2000.01319.x [PubMed] 20477783 Hanke AA, Dellweg C, Kienbaum P, Weber CF, Grlinger K, Rahe-Meyer N

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TXNDC12, as one of the PDI family members, is abnormally expressed in tumours such as gastric cancer and hepatocellular carcinoma, but the role of TXNDC12 in PAAD remains unknown

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