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Results Among 218 patients with available TMAO measurements, those in higher quartiles showed an increased all-cause mortality compared to the lowest quartile after 180 days (adjusted HR 1.92 95% CI 1.033.56, p = 0.04) and 5 years (adjusted HR 2.01 95% CI 1.233.31, p = 0.006)

Initially, we used fivefold cross-validation to determine the best regularization parameter lambda (from 100 values ranging from 10 3 to 10 5 ) for predicting circulating TMAO in the left-out group

The main diagnostic guides i.e ., the DSM-5 edited by the American Psychological Association (APA) and the International Classification of Diseases 11 th Revision (ICD-11) published by the World Health Organization (WHO) are considering this problem

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