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Most users take it on an empty stomach, but with food is fine if GI tolerance is an issue

Actiponin, a branded gynostemma pentaphyllum extract, assists in supporting metabolic flexibility and activating BAT, enabling your body to efficiently burn stored fat

10.3892/mmr.2019.10904 [DOI] [PMC free article] [PubMed] [Google Scholar]

Researchers emphasized that this non-invasive route could serve as a model for other neuroactive synthetic peptides, providing a foundation for future translational studies on neurodegenerative conditions

If you absolutely must have a drink, the lesser of two evils would be to have it much earlier in the dayfor example, a drink with a late lunch