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HepG2 cells were divided into groups: the control group, the model group (ethanol 200 mmol/L), the ML385 positive group (5 mol/L), the Germacrone group (GM-L: 0.5 mol/L, GM-M: 1 mol/L, GM-H: 2 mol/L), THBQ group (10 mol/L), THBQ + Germacrone group (0.5 mol/L, 1 mol/L)

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Folate supplementation may increase methionine and SAM levels 25 and, as a result, improve methylation