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However, as mentioned before these antioxidants have a very short half-life and are only effective after mild bouts of oxidative stress

de Jong, A

In vitro studies with liver cytosol showed that individuals with at least one copy of the GSTZ1A variant (KRT) exhibited higher activity with DCA than those without this variant, confirming studies with expressed recombinant GSTZ1A that showed higher activity than the other variants (Blackburn, et al., 2000

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In addition to enhancing antioxidant mechanisms to balance and maintain oxidative stress, tumor cells may activate prosurvival and antiapoptotic signaling pathways