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The approach to treatment of HCV-associated B-cell lymphomas highly depends on whether the tumor is an indolent (low-grade) or more aggressive tumor, as well as the B-cell tumor subtype.[93,100,101] Indolent B-Cell Lymphoma Multiple reports and studies in persons with HCV-associated B-cell non-Hodgkin lymphoma have shown that successful HCV treatment can cause regression of low-grade lymphomas.[102,103,104,105,106,107] In these individuals, some experts now recommend initiating HCV treatment with direct-acting antiviral therapy if there is no immediate need for chemotherapy, with very close follow-up.[101,108] Aggressive B-Cell Lymphomas Treatment of aggressive B-cell lymphoma with chemotherapy in persons with chronic HCV infection (with ongoing viremia) is associated with increased rates of hepatotoxicity when compared with persons who do not have active HCV infection

Another important role of NHR-49 in hypoxia relates to extracellular matrix remodelling

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