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While it is known that B-vitamin supplementation effectively treats hyperhomocysteinemia, there is a need for well-designed, large trials to evaluate the effect of B-vitamin supplementation on long-term outcomes, such as age-related cognitive decline and the incidence of Alzheimers disease

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However, the development of techniques such as fluorescent lifetime imaging and genetic reporter animals could help elucidate the true importance of astrocytic Na + homeostasis under physiological as well as pathological conditions

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