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Knockdown of PCSK9 with PCSK9 siRNA or induction of gain of function mutant D374Y-PCSK9 reduces expression of stress-response genes and specific inflammation pathways, inflammation pathway activation and OxLDL-induced endothelial apoptosis[266-268]

doi: 10.1007/s11892-016-0752-4 135 WenzlauJMGuYMichelsARewersMHaskinsKYuL

Accumulation of these compounds can result in oxidative stress, which occurs when the generation of free radicals in the body exceeds the bodys ability to neutralize and eliminate them

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