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10.1007/978-1-4615-5847-7_15 595 Szab.SzllsiJ.NagyP
PMID: 42121394 Genes (Basel)2026 Apr 25;17(5):510
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In this context, combining targeted ammonia metabolism intervention (e.g., using the GLS1 inhibitor CB-839) with CAR-T cell infusion not only blocks tumor cell utilization of ammonia but also enhances T cell adaptability through metabolic plasticity, thereby simultaneously alleviating the immunosuppressive microenvironment and prolonging CAR-T cell persistence (156, 159)
