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Consolidated guidelines on HIV prevention, testing, treatment, service delivery and monitoring: Recommendations for a public health approach

Lastly, in the advanced stage, collagen becomes heavily cross-linked, and phenotypic changes of fibroblasts to myofibroblasts (MFBs) along with an atrophic epithelium are observed, which increases the risk for epithelial dysplasia and oral squamous cell carcinoma (OSCC) (Passi et al., 2017)

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NAD+-Sirtuin2 reduces chronic low-grade inflammation and enhances the quantity and functionality of MuSCs