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Importantly, CHAC2 did not localize to the mitochondria irrespective of extracellular cystine availability, further suggesting divergent roles for these proteins in mediating intracellular GSH catabolism

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Interestingly, another study showed that NRF2 overexpression increased human telomerase reverse transcriptase (hTERT) levels and upregulated the expression of two PPP enzymes, G6PD and TKT, which could promote the progression of glioblastoma [100]

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