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GSTM1 gene encodes Glutathione S-transferase Mu 1 (GSTM1), a key phase II detoxification enzyme that catalyzes the conjugation of glutathione to electrophilic compounds, including toxic metabolites of cyclophosphamide such as acrolein and phosphoramide mustard (NCBI, 2025a) GSTM1 null genotype is the common polymorphism in GSTM1

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Under physiological conditions, NCMPs disassociate into the original nanoparticles and maintain the properties of the nanocarriers (nano complexes or nanoparticles), including their drug release and delivery advantages (Fig

Cystine dependency has been extensively studied using non-physiological tissue culture media, so whether media more closely matching conditions experienced by tumors in vivo would provide greater insight to cystine dependency in cancer cells is an unknown but intriguing question