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The authors proposed that L-carnitine regulates the PTEN/Akt/mTOR signaling pathway, and enhances axonal plasticity while concurrently ameliorating oxidative stress and increasing oligodendrocyte myelination of axons and suggested that this attenuated cognitive impairment after chronic hypoperfusion [86] However, the increased CPT I and CPT II protein levels in L-carnitine treated rats may also have protected myelin after chronic hypoperfusion

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In contrast, short-chain fatty acids at least up to octanoate can permeate the inner mitochondrial membrane in a non-esterified state, and they are activated to their CoA-derivatives in the mitochondrial matrix for use in energy-dependent mitochondrial processes

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Venipuncture Venous blood samples were obtained into 10 mL vacutainer tubes using a 21-gauge phlebotomy needle inserted into the antecubital vein