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doi:10.1016/S0140-6736(23)01302-8 Wharton S, Blevins T, Engberg S, et al

Prior studies indicate a potential mechanistic association between impaired intestinal barrier function and activation of arthritogenic immune cells [2,3,4]

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Namely, the study goal is to determine whether the compound is incorporated into the target tissue and where off target side effects might occur

What matters far more than the exact route is whether you needed the injection in the first place, and whether the dose and schedule are right
