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Description
Imeglimin prevents heart failure with preserved ejection fraction by recovering the impaired unfolded protein response in mice subjected to cardiometabolic stress
However, only BNSP333-OspA-HVG can fully deplete Bb after the challenge
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The compound was developed by Peter de Keizer and colleagues at Erasmus University Medical Center (Rotterdam) and published in a landmark 2017 Cell paper (Baar et al., Cell 169:132-147) demonstrating selective induction of apoptosis in cellular senescence research models
