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The agency would have to solicit public comment and an advisory committee of health and pharmacy experts would have to review the FDAs research
Bergapten, an LXR agonist, impedes the onset and progression of HCC by regulating the LXR/PI3K/Akt and LXR/IDOL/LDLR pathways and decreasing LDLR expression in a dose-dependent manner [254]

In 16% of cases, the primary site remains unknown