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Unlike injectable GLP-1 receptor agonists, bacterial systems exhibit high inter-individual variability in peptide expression and secretion, influenced by diet, baseline microbiota composition, and immune status
63,65,66,70 Meta-analysis, epidemiological, and clinical follow-up studies have all shown a strong correlation between AKI episodes and subsequent development of CKD
380 Activated ERK1/2 switches LSECs to a pro-regenerative phenotype by releasing HGF and Wnt, whereas activated AKT triggers the profibrotic phenotype of LSECs
