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The Mitochondrial Nature of the DNA Repair Protein Ape1

Thus, inhibiting CXCR2 could serve as a novel method for treating cisplatin-induced hearing loss

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Analogous redox control occurs for AP-1 and other transcription factors where ROS-induced oxidation stimulates cytosolic activation, but a reducing environment is required for nuclear DNA binding and activation of transcription (169)

[PubMed: 193398] 225
