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Think of it like a grape versus a raisin

In our design, Mn/TI@mHSA nanoassemblies are engineered to spontaneously disassemble into smaller protein blocks upon exposure to ROS, thereby facilitating deep penetration into plaques

6,18,19,20,21 On the other hand, copper inhibits tumor growth by participating in the regulation of cell death processes, including apoptosis, pyroptosis, necroptosis, ferroptosis, and autophagy, as well as by activating immune responses

In contrast, cancers with high expression of only one or two enzymes display metabolic flux redirection or environmental dependence, requiring combination strategies targeting transporter bypass pathways or microenvironmental remodeling cascades