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Phospholipids and their hydroxy and hydroperoxy derivatives, including 15-HETE-PE and 15-HpETE-PE, were analyzed by LC/MS using a Dionex Ultimate 3000 HPLC system coupled on-line to an Orbitrap Fusion Lumos mass spectrometer (Thermo Fisher Scientific) using a normal phase column (Luna 3 m silica C18(2) 100 , 150 2.0 mm, Phenomenex)

Hands: The backs of the hands are among the first areas to show sun damage and age spots

The asparagine-glycine sequence forms a cyclic imide intermediate that can hydrolyze into either aspartate or iso-aspartate, fundamentally altering the peptide structure

Winer A, Adams S, Mignatti P

2015, pp