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first proposed the concept of oxidative stress, either caused by an increase in free radical production or a reduction in the scavenging capacity of the body, leading to disorders in the oxidation and antioxidant systems, resulting in oxidative damage by free radical accumulation (Sohal and Allen, 1990)

Furthermore, abemaciclib and IRR (10 Gy) induced a non-significant decrease in the level of IL-6 in the cell lysate of MCF-7 and a significant reduction in the level of IL-6 in MDA-MB-231 cell lines compared to the abemaciclib-treated cells of each cell line (Fig