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Furthermore, elevated MCP-1 levels as a result of chemokine upregulation associated with neuroinflammatory diseases have been shown to be associated with increased BBB permeability, which can further exacerbate disease progression [26]

A generative AI framework was then employed to link and optimize fragments into complete molecules, leading to the identification of four lead compounds with favorable selectivity and drug-like properties after rigorous filtering

Molecular biomarkers in cardiac hypertrophy

Telomerase promotes stem cell activation, inhibits apoptosis, mitigates oxidative stress, and enhances cellular vitality

Hum Genet (2020)