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Compared with the Control group, the IMQ and CMH@lip groups showed extensive neutrophil accumulation

However, since a larger fraction of the total drug in the body is now free, the steady-state concentration of free drug increases significantly, posing a major risk of toxicity

Functional testing can reveal hidden drivers missed in conventional care oxidative stress markers (e.g., 8-isoprostane), mitochondrial biogenesis regulators (e.g., PGC-1), microbiome mapping, endotoxin load, and environmental toxin panels

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The study outlines key factors impacting the effectiveness of novel herbal formulations, including preparation methods, active ingredients, route of administration, entrapment efficiency, and formulation activity [86]