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However, for more severe endothelial dysfunction, chronic venous insufficiency, or significant cognitive impairment, studies frequently employ doses of 150 mg to 200 mg per day, typically divided into two doses (e.g., 100 mg in the morning and 100 mg in the evening)

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These antioxidants in rats treated with scopolamine were significantly decreased in the present study (Figure 3) which could result in increased oxidative stress

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[DOI] [PubMed] [Google Scholar] 116.Perricone C, De Carolis C, Perricone R