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Individuals with Gastrointestinal Conditions: Certain gastrointestinal conditions, such as celiac disease, Crohns disease, or gastrointestinal surgery, can impair nutrient absorption

Rigorous human studies are required to determine safety parameters, mechanistic specificity, and potential translational relevance before any clinical applications can be considered

The results of a sequential supplementation trial in 53 men and women indicated that after optimization of folate status with folic acid supplements, vitamin B 12 became the major determinant of plasma homocysteine levels (30)