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Phase II Clinical Trials These promising preclinical findings led to Phase I and Phase II clinical trials in humans

[DOI] [PMC free article] [PubMed] [Google Scholar] 25.Jeffers M, Schmidt L, Nakaigawa N, Webb CP, Weirich G, Kishida T, Zbar B, Vande Woude GF

In studies combining NNMT inhibition with progressive weighted wheel running (an intensive concurrent endurance and resistance exercise protocol), treated mice exhibited sustained enhanced muscle performance suggesting reduced need for recovery between exercise sessions

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Abstract Aims/hypothesis Both manifestations of kidney disease in diabetes, reduced eGFR (ml/min per 1.73 m 2 ) and increased urinary albumin/creatinine ratio (UACR, mg/mmol), may increase the risk of specific CVD subtypes in adults with diabetes