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Outcome measures cover wet muscle weight recovery, isometric and isotonic force generation, histological assessment of regenerated fibers, and immunohistochemistry for myogenic markers like MyoD and myogenin

Severe reactions are rare but may occur in individuals with sensitivity to cobalamin injections or high-dose supplements

M., Procter, J

The results across this body of literature are consistently positive: Tendon and ligament healing: Accelerated structural repair in Achilles tendon rupture and ACL tear models, with improved tensile strength and histological organization

Some conditions that are especially benefited by increasing NAD+ levels are: See list of conditions benefitted by NAD+ Substance Abuse Depression Addiction Chronic Pain Sleep Disorders Brain Injury Autism Mitochondrial Disease Lyme Disease Chronic Fatigue Improving Physical Performance in Athletics Anxiety Neurodegeneration You will notice that many of the conditions mentioned involve suboptimal functioning of the brain and nervous system