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Antagonizing LINGO-1 in the cuprizone model enhanced differentiation of OPC and promoted remyelination (Mi et al., 2009) and remyelination was accelerated in ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 4 (St8siaIV, the polysialyltransferase responsible for PSA synthesis) knockout mice (Koutsoudaki et al., 2010), suggesting that these molecular mechanisms are indeed involved in remyelination
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