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Mild headache in the first week or two is the most frequently reported side effect

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By eliminating folic acid and dairy, supporting methylation, and supplementing with folinic acid or methylfolate, many patients' health is supportedespecially when treatment begins early

Interestingly, TRAP1 appears to act downstream of PINK1 to prevent mitochondrial dysfunction associated with PD pathogenesis [108], a mechanism also validated in Drosophila models [107]

Since endothelin similarly contracts lymphatic vessels, we speculate that a similar mechanism may be at play in the pathogenesis of primary lymphedema