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Non-alcoholic fatty liver disease is mainly caused by health and lifestyle factors such as obesity, diabetes, high blood pressure, high cholesterol, a diet high in fat, carbohydrates, or sugar, lack of regular exercise, side effects from certain medications, hepatitis virus infection, or genetic abnormalities

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Inhibitors of the IL-8 receptor CXC chemokine receptor 2 (CXCR2) effectively block neutrophil infiltration in the lung tissue in animal models and clinical trials

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[0411] In certain embodiments the cytotoxic/cytostatic agent comprises a protein or peptide toxin or fragment thereof