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have demonstrated that PHF19 , an epigenetic gene correlated with poor prognosis in MM patients, mediates the immunosuppressive BM microenvironment by promoting induced Treg frequency, and decreasing CD38 expression on MM cells

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In addition, animal study shows that cyclosporine induces hepatic GSH depletion, while renal GSH remains unaffected (Jimenez et al., 2000)