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Although we have shown a strong association between upstream p38 MAPK inhibition and downstream Nrf2 activation coupled with functional improvementand this regulatory relationship is consistent with established mechanismsdirect experimental confirmation of Nrf2s necessity in this pathway, such as through the use of Nrf2-specific inhibitors or genetic knockout approaches, will be required in future work

Yamada, T., Kimura, Y., et al

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Iloprost and vitamin C attenuates acute myocardial injury induced by suprarenal aortic ischemia-reperfusion in rabbits

[DOI] [PMC free article] [PubMed] [Google Scholar] 159.Orekhov AN, Poznyak AV, Sobenin IA, Nikifirov NN, Ivanova EA