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1Alpha,25-dihydroxyvitamin D3 attenuates cyanide-induced neurotoxicity by inhibiting uncoupling protein-2 up-regulation

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Notably, therapeutic interventions targeting LDHAa key glycolytic enzymereverse lactate-driven acidification and restore oxidative metabolism in PF models, mirroring findings in cystic fibrosis where CFTR mutations similarly elevate lactate through mitochondrial dysfunction (Newton et al., 2021

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Microbiol Spectr 10(4):e0165822 Coburn PS et al (2016) Bloodstream-to-eye infections are facilitated by outer blood-retinal barrier dysfunction