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Integrating the biophysical and molecular mechanisms of auditory hair cell mechanotransduction

Coniferyl ferulate blocks the NMDAR/NR2B-CaMKII-MAPKs signaling pathway, inhibits ROS production and mitochondrial apoptosis, while reshapes the intestinal microbiota and microbial metabolism, ameliorates colonic inflammation and alleviates depressive symptoms in mice

2007;44 Suppl 1:213-6

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As a result, the balance in the ROS levels is disrupted, contributing to an increased susceptibility to oxidative stress (Gallegos-Arreola et al., 2020)