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Yilmaz et al., 2022)

Enzyme-mediated lysine lactylation The precise execution of enzyme-mediated lactylation requires the assistance of specialized tools

(PubMed) Shults CW, Oakes D, Kieburtz K, et al

However, it is not only possible to combine SA with other chemicals

Thus, GPx4 activity is a central molecular switch in the ferroptosis pathway, and the System XcGSH-GPx4 axis is also a central pathway in the ferroptosis pathway, in which a key member, inhibitory SLC7A11 (solute carrier family 7 member 11), inactivates GPx4 and increases lethal reactive oxygen species by blocking the entry of cysteine into the cell, thereby reducing GSH synthesis and ultimately inducing ferroptosis