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10.1016/j.ijbiomac.2016.12.085 94 MennigenR.NolteK.RijckenE.UtechM.LoefflerB.SenningerN.et al (2009)

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As with all GLP-1 agonists, long-term post-marketing surveillance will be essential to characterize the pancreatic safety profile with greater statistical precision, particularly for rare events such as acute pancreatitis (estimated background rate of approximately 35 per 100,000 person-years in the general population) and the theoretical concern about pancreatic cancer

Some United Healthcare and Aetna policies, for example, apply NCCI-like bundling edits that go beyond standard CMS edits and require Modifier 59 to bypass the edit rather than Modifier 25