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A series of randomized controlled trials by Jensterle and colleagues published between 2014 and 2022 established that liraglutide outperformed metformin on weight loss, menstrual frequency, and androgen reduction in women with obesity and PCOS.[6] It produces less weight loss than semaglutide or tirzepatide, but it carries the longest PCOS-specific track record of the three

With the exception of semaglutide and tirzepatide in their brand forms, the substances described are not FDA-approved drugs for the uses discussed

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