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Given an increasingly aging population globally and projected increase in associated dementia (Livingston et al., 2017

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Peripheral neuropathy can present as either distal sensory polyneuropathy or vasculitis-mediated mononeuritis multiplex.[22] Diagnosis of Cryoglobulinemic Vasculitis Specific diagnostic criteria or classification for cryoglobulinemic vasculitis have not yet been defined.[22] The diagnosis is typically made from the combination of history, skin findings, low complement levels, presence of cryoglobulins in serum, and histology that shows small vessel inflammation with immune deposits found in the vascular walls.[22] Treatment of HCV-related Cryoglobulinemic Vasculitis The approach to treating HCV-related cryoglobulinemic vasculitis is complex and depends on the severity of the cryoglobulinemia and end-organ involvement