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It also appears to influence cell proliferation and modulate inflammation, with different molecular weights, such as LMW and HMW, exhibiting distinct biological activities

These data indicate that the lack of agreement in findings on melatonin levels in depressed individuals may be a result of (1) the diversity of behavioral and etiological phenomena in depressive states [as previously commented ( Though the immediate mechanisms of action of current antidepressants are well-understood, the delay in clinical outcome conveys the gap of knowledge on the complete pathways that ultimately determine the clinical response
