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To further examine the impact of protein synthesis we examined the impact of decreasing the rate of protein synthesis by using a strain that expresses the constitutively active allele of AMPK CA-AAK-2 which leads to similar phenotypes to those observed during dietary restriction (24)

[5] The methylation cycle hypothesis states that many if not all of the symptoms of CFS are caused by errors in the genes that regulate or have a strong impact on one-carbon metabolism, such as MTHFR, CBS, DHPR, MTRR, or MAO-A

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