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Janicka A, Szymanska-Pasternak J, Bober J

Cytochrome P450 enzymes mediate tamoxifen biotransformation, CYP3A4, CYP2B6, CYP2C9, CYP2C19 and CYP2D6 are the essential isoenzymes for this process

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In particular, central myelin degeneration promoted by pathological interactions involving both peripheral and central cell-mediated immune attacks induces the accumulation of dysfunctional myelin and neurological deficits 1,11

As with any research compound, it is important to review available literature, understand study findings, and evaluate data carefully