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Acknowledgements The work of the authors cited in this review was partially supported by the Institut National de la Sant et de la Recherche Mdicale (INSERM), the Conseil Rgional de Bourgogne, and the Universit de Bourgogne

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These barriers necessitate formulations that are (i) prolong residence time, (ii) protect drugs from enzymatic degradation, and (iii) enhance permeability without compromising long-term nasal tolerability