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doi: 10.1023/a:1015345827091

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Conversely, in CRPC, levels of anti-inflammatory cytokines including IL-4, IL-6, and IL-10 are elevated, while TNF- and IL-17 upregulate PD-L1 expression, further intensifying immunosuppression (Cheng et al., 2024)

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It works by blocking an enzyme called NNMT (nicotinamide N-methyltransferase)