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Niacin causes vasodilation and flushing due to activation of the GPR109A receptor, while niacinamide does not

doi: 10.1111/mmi.12967 57 McDuffeeA

Clinical studies show efficacy at concentrations as low as 0.01 nM, with optimal results at 1100 nM (Maquart et al., 2015)

In the HCQS and polyherb groups, there was an improvement in efficacy measures no difference among the groups (significant P values)