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The most extensively documented involves upregulation of vascular endothelial growth factor (VEGF) and its receptor VEGFR2, promoting angiogenesis, the formation of new blood vessels, in injured tissue

doi: 10.1002/eji.202350901 20 CeppelliniRGarottaGMalavasiFTruccoM

The standard cycle is 8 to 12 weeks on, followed by 4 to 8 weeks off

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Sterile water without preservative is generally discussed in single-use preparation contexts
