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Indeed, gut dysbiosis, especially related to obesity of high-fat diet, can increase EC activity, thus, determining an increased gut permeability and consequent LPS translocation

Gan Y, Li S, Li P, Xu Y, Wang L, Zhao C, et al

244HillPShuklaDTranMGAragonesJCookHTCarmelietPMaxwellPH

References & More Injection Techniques in Musculoskeletal Medicine

This is a judgment call that depends on specific circumstances and how questions are phrased
