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Its effect was associated with a significant decrease in oxidative stress parameters and likely maintained NO system function, providing that BPC 157 interacted with eNOS and COX2 gene expression, in a particular way and counteracted the noxious effect of the NOS-blocker, L-NAME

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29 Ligamentous instability and tears (incidence: 46/100,000 person-years 30 ), and meniscectomies (incidence: 224/100,000 31 ) further compound the high risk of progression to OA 32 and increase the likelihood of patient exclusion