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Previous studies have demonstrated that down-regulation of the expression of Trx, either by small molecule compounds or by genetic means, could affect the drug sensitivity of the tumor [14, 15]

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however, it does suggest checking 12 months after treatment if there is no clinical response

Achard, P

10.1074/jbc.274.10.6039 27 ChenY.LiangZ.BlanchardJ.DaiC.-L.SunS.LeeM
