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3 Impact of tobacco smoke on enzymatic drug metabolism Tobacco smoke is a complex mixture of polycyclic aromatic hydrocarbons (PAHs), ammonia, aromatic amines, phenols, carbonyls, hydrocyanic acid, and N-nitrosamines (Hoffmann and Hoffmann, 1997)

[DOI] [PMC free article] [PubMed] [Google Scholar] 81.Liu C.-T., Brooks G.A

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