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One study raised an interesting point: circadian clock-related gene expression may exist in the pituitary, and this expression is related to the expression of GH gene ( CLOCK gene and the BMAL1 gene was not high, which was consistent with the view that different parts of the circadian clock system linked to different functions as circadian oscillators ( CLOCK, PER1, PER2, CRY3, NRLD2 ) showed the difference of expression oscillation in the pituitary of GH transgenic and wild type coho salmon, which indicated that the GH gene might have a regulatory effect on the expression of pituitary clock genes

Next, we further explore the mechanisms about stress-induced hepatocyte premature aging

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McEvoy 2012), including atherosclerosis (AS), myocardial infarction (MI), heart failure (HF), diabetic cardiomyopathy (DCM), hypertension, ischemic stroke (IS), and so on

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